Naegele Lab

Mirsky, J. and Naegele, J.R. (submitted) Neuroprotection of hippocampal neurons in the dentate gyrus and CA1 by serotonin receptor activation prior to status epilepticus.

Aaron, G.A., Briggs, S., Lombroso, P.J., Naegele, J.R. (under revision) STEP regulation of epileptogenesis in the hippocampus.

Naegele, J.R. (2010) Trekking through the telencephalon: hepatocyte growth factor-mediated guidance for parvalbumin-expressing interneurons. Epilepsy Currents 10(4). In press.

Naegele J.R., Maisano, X., Yang, J.,  Royston, S., and Ribeiro, E. (2010) Transplants for brain repair in epilepsy and neurodegenerative diseases. Neuropharmacology 58: 855-864. Special Issue entitled: Drugs and Stem Cells for Brain Repair.

Naegele, J.R. (2010) Westward Ho! Pioneering mouse models for X-linked infantile spasms syndrome. Epilepsy Currents 10(1): 1-4.

Hartman, N., Grabel, L.B., and Naegele, J.R. (2010) Migration of transplanted neural stem cells in models of neurodegenerative diseases. Stem Cells and Regenerative Medicine. Appasani K (Ed.) Springer Science (Humana Press). In press

Naegele, J.R. and Maisano,. X. (2010) Gene and stem cell therapies for treating epilepsy. Rho J.M., Sankar R., Stafstrom C.E. (Eds.). Epilepsy: Mechanisms, Models, and Translational Perspectives, Dekker M, Inc. (CRC Press). In press.

Naegele, J.R. (2009) Epilepsy and the plastic mind. Epilepsy Currents 9(6): 166-169.

Liu J, Naegele J.R, and Lin, S.L. (2009) The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation. Brain Research 1296: 164-175.

Maisano, X., Carpentino, J., Becker, S., Lanza, R., Aaron, G., Grabel, L., and Naegele, J.R. (2009) Embryonic stem cell-derived neural precursor grafts for treatment of temporal lobe epilepsy. Neurotherapeutics 6(2): 263-277.

Choi Y. -S., Cho, H. -Y., Hoyt, K.R., Naegele, J.R., and Obrietan, K. (2008) IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus. Glia 56(7): 791-800.

Carpentino, J.E., Hartman, N., Grabel, L.B., and Naegele, J.R. (2008) Region specific differentiation of embryonic stem cell-derived neural progenitor transplants in the adult mouse hippocampus following seizures. J. Neuroscience Research 86(3): 512-524.

Choi, Y-S, Lin, S.L., Lee, B., Kurup, P., Cho, H-Y. and Naegele, J.R., Lombroso, P.J., Obrietan, K. (2007) Status epilepticus-induced somatostatinergic hilar interneuron degeneration is regulated by striatal enriched protein tyrosine phosphatase.  J. Neuroscience 27(11): 2999-3009.

Naegele, J.R. (2007) Neuroprotective strategies to avert seizure-induced neurodegeneration in epilepsy. Epilepsia 48(Supplement 2): 107-117.

Navarro-Quiroga, I., Hernandez-Valdes, M., Lin, S.L., and Naegele, J.R. (2006) Postnatal cellular contributions of the hippocampus subventricular zone to the dentate gyrus, corpus callosum, fimbria, and cerebral cortex. J. Comp. Neurol. 497(5): 833-845.

Neema, M., Navarro-Quiroga, I., Chechlacz, M., Gilliams-Francis, K., Liu, J., LaMonica, K., Lin, S., and Naegele J.R. (2005) DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. Hippocampus 15(8): 1057-1071.

Narasimhaiah, R., Tuchman, A., Lin, S.L., and Naegele, J.R. (2005) Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice. Cerebral Cortex 15(6): 696-707.

Gilliams-Francis, K.L., Quaye, A., and Naegele, J.R. (2003) PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death. Exp. Neurol. 184(1): 359-372.

Chechlacz, M. and Naegele, J. (2002) Genetics of childhood disorders: XL. Stem cell research, part 4: neural horticulture. J. Am. Acad. Child Adolesc. Psychiatry 41(7): 882-5.

Chechlacz, M., Vemuri, M., and Naegele, J.R. (2001) Role of DNA-dependent protein kinase in neuronal survival. J. Neurochem. 78(1): 141-54.

Naegele, J.R. and Lombroso, P.J. (2001) Genetics of central nervous system developmental disorders. Child Adolesc. Psychiatry. Clin. N. Am. 10(2): 225-39.

Vemuri, M., Schiller, E., and Naegele, J.R. (2001) Elevated DNA double strand breaks and apoptosis in the CNS of SCID mutant mice. Cell Death Differ. 8(3): 245-255.

Upender, M.B. and Naegele, J.R. (1999) Activation of microglia during developmentally regulated cell death in the cerebral cortex. Dev. Neurosci. 21(6): 491-505.

Naegele, J.R. and Lombroso, P.J. (1998) Apoptosis in the cerebral cortex. J. Am. Acad. Child Adolesc. Psychiatry. 37(8): 890-892.

Upender, M.B., Dunn, J.A., Wilson, S.M., and Naegele, J.R. (1997) Immunoglobulin molecules are present in early-generated neuronal populations in the rat cerebral cortex and retina. J. Comp. Neurosci. 384: 271-282.

Bult, A., Zhao, F., Dirkz, R., Sharma, E., Lukacsi, E., Solimena, M., Naegele, J.R., and Lombroso, P. (1996) STEP61: A new member of a family of brain-enriched PTPs is targeted to the endoplasmic reticulum. J. Neurosci. 16: 7821-7831.

Upender, M. and Naegele, J.R. (1996) Preparation and growth of embryonic neurons in tissue culture. In: Neuroscience Methods: The Undergraduate Laboratory Experience, (D.G. Blackburn, ed.), Trinity College Press, Hartford, CT.

Raghunathan, A., Matthews, G.A., Lombroso, P.J., and Naegele, J.R. (1996) Transient compartmental expression of a family of protein tyrosine phosphatases in the developing striatum. Develop. Brain Res. 91(2): 190-199.

Spicer, S.S., Naegele, J.R., and Schulte, B.A. (1996) Differentiation of glycoconjugates localized to sensory terminals and selected sites in brain. J. Comp. Neurol. 365(2): 217-231.

Dunn, J.A., Kirsh, J., and Naegele, J.R. (1995) Transient immunoglobulin-like molecules are present in the subplate zone and cerebral cortex during postnatal development. Cerebral Cortex 5: 494-505.

Boulanger, L., Lombroso, P.L., Raghunathan, A., During, M.J., Wahle, P.R., and Naegele, J.R. (1995) Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. J. Neurosci. 15(2):1532-1544.

During, M.J., Naegele, J.R., O’Malley, K., and Geller, A.I. (1994) Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266: 1399-1403.

Wahle, P., Lubke, J., and Naegele, J.R. (1994) Inverted pyramidal neurons and interneurons in cat cortical subplate zone are labeled by monoclonal antibody SP-1. Eur. J. Neurosci. 6: 1167-1178.

Naegele, J.R. and Lombroso, P.J. (1994) Protein tyrosine phosphatases in the nervous system. Reviews in Neurobiology 9(1): 105-114.

Lombroso, P.J., Naegele, J.R., Sharma, E., and Lerner, M. (1993) A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures. J. Neurosci. 113(7): 3064-3074.

Barnstable, C.J., Kosaka, T., Naegele, J.R., and Arimatsu, Y. (1992) Molecular properties of GABAergic local-circuit neurons in the mammalian visual cortex. Prog. Brain Res. 90:503-522.

Naegele, J.R. and Barnstable, C.J. (1991) A carbohydrate epitope defined by monoclonal antibody VC1.1 is found on N-CAM and other cell adhesion molecules. Brain Res. 559(1): 118-129.

Naegele, J.R., Barnstable, C.J., and Wahle, P.R. (1991) Expression of a unique 56-kDa polypeptide by neurons in the subplate zone of the developing cerebral cortex. Proc. Natl Acad. Sci. (USA) 88: 330-334.

Zaremba, S., Naegele, J.R., Barnstable, C.J. and Hockfield, S. (1990) Neuronal subsets express multiple high-molecular-weight cell-surface glycoconjugates defined by monoclonal antibodies Cat-301 and VC1.1. J. Neurosci. 10(9): 2985-2995.

Naegele, J.R. and Katz, L.C. (1990) Cell surface molecules containing N-acetylgalactosamine are associated with basket cells and neurogliaform cells in cat visual cortex. J. Neurosci. 10(2): 540-557.

Naegele, J.R. and Barnstable, C.J. (1989) Molecular determinants of GABAergic local-circuit neurons in the visual cortex. Trends Neurosci. 12(1): 28-34.

Naegele, J.R., Jhaveri, S. and Schneider, G.E. (1988) Sharpening of topographical projections and maturation of geniculocortical axon arbors in the hamster.J. Comp. Neurol. 277(4): 593-607.

Naegele, J.R., Arimatsu, Y., Schwartz, P. and Barnstable, C.J. (1988) Selective staining of a subset of GABAergic neurons in cat visual cortex by monoclonal antibody VC1.1. J. Neurosci. 8(1): 79-89.

Arimatsu, Y., Naegele, J.R. and Barnstable, C.J. (1987) Molecular markers of neuronal subpopulations in layers 4, 5, and 6 of cat primary visual cortex.J. Neurosci. 7(4): 250-263.

Birch E.E., Gwiazda, J., Bauer, J.A., Naegele, J.R., and Held, R. (1983) Visual acuity and its meridional variations in children aged 7-60 months. Vision Res. 23(10): 1019-1024.

Naegele, J.R. and Held, R. (1982) The postnatal development of monocular optokinetic nystagmus in infants. Vision Res. 22(3): 341-346.