Naegele Lab Publications

Peer-reviewed manuscripts (reverse chronological order)

Arshad MN, Aaron GB, Naegele JR (2020) Retroviral labeling, optogenetics, and patch-clamp electrophysiology to study synaptic integration of channelrhodopsin-expressing GABAergic interneurons transplanted into the mouse brain. Robert E Dempski (ed.),  Channelrhodopsin: Methods and Protocols, Methods in Molecular Biology, 2191, https://10.1007/978-1-0716-0830-2_8, Springer Science+Business Media.

Shrestha S, Anderson NC, Grabel LB, Naegele JR, Aaron GB (2020)  Development of electrophysiological and morphological properties of human embryonic stem cell-derived GABAergic interneurons at different times after transplantation into the mouse hippocampus PLoS One. Aug 19;15(8):e0237426. doi: 10.1371/journal.pone.0237426. eCollection 2020. PMID: 32813731

Arshad MN and Naegele JR (2020). Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine. Bio-protocol 10(4): e3533. DOI: 10.21769/BioProtoc.3533.

Gupta J, Bromwich M, Radell J, Arshad MN, Gonzalez S, Luikart BW, Aaron GB, Naegele JR (2019) Restrained Dendritic Growth of Adult-born Granule Cells Innervated by Transplanted Fetal GABAergic Interneurons in Mice with Temporal Lobe Epilepsy. eNeuro May 1; May 1;6(2). pii: ENEURO.0110-18.2019. doi: 10.1523/ENEURO.0110-18.2019. Print 2019 Mar/Apr. PMID:31043461

Van Zandt M, Weiss E, Almyasheva A, Lipior S, Maisel S, Naegele JR (2019) Adeno-associated viral overexpression of neuroligin 2 in the mouse hippocampus enhances GABAergic synapses and impairs hippocampal-dependent behaviors. Behav Brain Res. 2019 Apr 19;362:7-20. doi: 10.1016/j.bbr.2018.12.052. Epub 2018 Dec 31. PMID: 30605713

Anderson NC, Van Zandt MA, Shrestha S, Lawrence DB, Gupta J, Chen CY, Harrsch FA, Boyi T, Dundes CE, Aaron G, Naegele JR, Grabel L.(2018) Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain. Stem Cell Res. 2018 Dec;33:83-94. doi: 10.1016/j.scr.2018.10.007. Epub 2018 Oct 5. PMID: 30340090

Xiang Y, Tanaka Y, Petterson B, Kang Y-J, Govindaiah G, Roselaar N, Cakir B, Kim K-Y, Lombroso AP, Hwang S-M, Zhong M, Stanley EG, Elefanty AG, Naegele JR, Lee S-H, Weissman SM, Park I-H. (2017) Fusion of regionally specified hPSC-derived organoids models human brain development and interneuron migration. Cell Stem Cell Sep 7; 21(3): 383-398.e7 PMID: 28757360

Hsieh L, Wen J, Claycomb K, Huang Y, Harrsch F, Naegele JR, Hyder F, Buchanan G, and Bordey A (2016) Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Nature Communications 1;7:11753. PMID: 27249187.

Henderson KW, Gupta J, Tagliatela S, Litvina E, Zheng XT, Van Zandt MA, Woods N, Grund E, Lin D, Royston S, Yanagawa Y, Aaron GB, Naegele JR (2014) Long-term seizure suppression and optogenetic analyses of synaptic connectivity in epileptic mice with hippocampal grafts of GABAergic interneurons. J Neurosci. Oct 1; 34(40): 13492-13504. PMID: 25274826

Germain ND, Banda EC, Becker S, Naegele JR, Grabel LB (2013) Derivation and isolation of NKX2.1-positive basal forebrain progenitors from human embryonic stem cells. Stem Cells Dev. 2013 May 15; 22(10): 1477-89. PMID: 23351095

Germain N, Hartman N, Becker S, Cai C, Naegele JR, Grabel LB (2012). Teratoma formation in embryonic stem cell-derived neural progenitor hippocampal transplants. Cell Transplantation. Cell Transplant. 21(8): 1603-11. Epub 2012 Jul 5. PMID: 22776287

Goebel-Goody S, Wilson-Wallis E, Royston S, Tagliatela S, Naegele JR, Lombroso P (2012) Genetic manipulation of STEP reverses behavioral abnormalities in a Fragile X syndrome mouse model. Genes Brain Behav. Jul; 11(5): 586-600. doi: 10.1111/j.1601-183X.2012.00781.x. Epub 2012 Apr 6. PMID: 22405502

Maisano X, Litvina E, Tagliatela S, Aaron GB, Grabel LB, Naegele JR (2012). Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy. J Neurosci Jan 4; 32(1): 46-61.

Briggs SW, Walker J, Asik K, Lombroso P, Naegele JR, Aaron G. (2011) STEP regulation of seizure thresholds in the hippocampus. Epilepsia. Mar; 52(3): 497-506.

Hartman NW, Carpentino JE, LaMonica K, Mor DE, Naegele JR, Grabel L (2010) CXCL12-Mediated Guidance of Migrating Embryonic Stem Cell-Derived Neural Progenitors Transplanted into the Hippocampus. PLoS One. 2010 Dec 31; 5 (12): e15856.

Liu J, Naegele JR, Lin, SL (2009) DNA-dependent protein kinase catalytic subunit regulates Bax-mediated excitotoxic neuronal death by Ku70 phosphorylation. Brain Research 1296:164-175.

Carpentino JE, Hartman N, Grabel LB, Naegele JR (2008) Region specific differentiation of ES-derived neural progenitor transplants in the adult mouse hippocampus following seizures. J Neurosci Res 86:512-524.

Choi Y-S, Cho H-Y, Hoyt KR, Naegele JR, Obrietan K (2008) Status epilepticus induced neuronal stem cell proliferation is stimulated by sequential waves of NMDA- and IGF-1 receptor-mediated ERK/MAPK signaling. Glia 56:791-800.

Choi Y-S, Lin SL, Lee B, Kurup P, Cho H-Y, Naegele JR, Lombroso PJ, Obrietan K (2007) Status epilepticus-induced somatostatinergic hilar interneuron degeneration is regulated by striatal-enriched protein tyrosine phosphatase. J Neurosci 27:2999-2009.

Navarro-Quiroga I, Hernandez-Valdes M, Lin S, Naegele JR (2006) Postnatal cellular contributions of the hippocampal subventricular zone to the dentate gyrus, corpus callosum, fimbria and cerebral cortex. J Comp Neurology 497:833-845.

Neema M, Navarro-Quiroga I, Chechlacz M, Gilliams-Francis K, Liu J, LaMonica K, Lin S, and Naegele JR (2005) DNA damage and non-homologous end-joining in excitotoxicity: neuroprotective role of DNA-Pkcs in kainic acid-induced seizures. Hippocampus 15:1057-1071.

Narasimhaiah R, Tuchman A, Lin SL, Naegele JR (2005) Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice. Cerebral Cortex 15:696-707.

Gilliams-Francis K, Quaye, A and Naegele JR (2003) PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death. Exp Neurol 184:359-372.

Chechlacz M, Vemuri M, and Naegele JR (2001) Role of DNA-dependent protein kinase in neuronal survival. J Neurochem 77:1-15.

Vemuri M, Schiller E, and Naegele JR (2001) Elevated DNA double strand breaks and apoptosis in the CNS of SCID mutant mice. Cell Death and Differentiation 8:245-255.

Upender MB and Naegele JR (1999) Activation of microglia during developmentally regulated cell death in the cerebral cortex. Developmental Neuroscience 21:491-505.

Upender MB, Dunn JA, Wilson SM, and Naegele JR (1997) Immunoglobulin molecules are present in early-generated neuronal populations in the rat cerebral cortex and retina. J Comp Neurology 384:271-282.

Bult A, Zhao F, Dirkz R, Sharma E, Lukacsi E, Solimena M, Naegele JR, and Lombroso P (1996). STEP61: A new member of a family of brain-enriched PTPs is targeted to the endoplasmic reticulum. J Neurosci 16:7821-7831.

Spicer SS, Naegele JR, and Schulte BA (1996) Differentiation of glycoconjugates localized to sensory terminals and selected sites in brain. J Comp Neurology 365:217-231.

Raghunathan A, Matthews GA, Lombroso PJ and Naegele JR (1996) Transient compartmental expression of a protein tyrosine phosphatase in developing striatum. Dev Brain Res 91:190-199.

Boulanger L, Lombroso PJ, Raghunathan A, During MJ, Wahle PR, and Naegele JR (1995). Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase. J Neurosci 15:1532-1544.

Bult A, Naegele JR, Sharma E and Lombroso PJ (1995). Identifying and characterizing protein tyrosine phosphatases in the brain. NeuroProtocols 6:91-104.

Dunn JA, Kirsch J and Naegele JR (1995) Transient immunoglobulin-like molecules are present in the subplate zone and cerebral cortex during postnatal development. Cerebral Cortex. 5:494-505.

Wahle P, Lubke J and Naegele JR (1994) Inverted pyramidal neurons and interneurons in cat cortical subplate zone are labeled by monoclonal antibody SP1. Eur J Neurosci 6: 1167-1178.

During MJ, Naegele JR, O’Malley K and Geller AI (1994) Long-term behavioral recovery in the rat model of Parkinson’s Disease by intrastriatal injection of a HSV-1 vector expressing tyrosine hydroxylase. Science 266:1399-1403.

Lombroso PJ, Naegele JR, Sharma E, and Lerner M (1993) A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures. J. Neurosci. 13:3064-3074.

Barnstable CJ, Kosaka T, Naegele JR and Arimatsu Y (1992) Molecular properties of GABAergic local-circuit neurons in the mammalian visual cortex. Mize, R.R. Marc, R.E. and Sillito, A.M., Eds; GABA in the Retina and Central Visual System. Prog in Brain Res Vol. 90: 503-522.

Naegele JR, Barnstable CJ, and Wahle PR (1991) Expression of a unique 56 kDa polypeptide by neurons in the subplate zone of the developing cerebral cortex. PNAS (USA) 88:330-334.

Naegele JR and Barnstable CJ (1991) A carbohydrate epitope defined by monoclonal antibody VC1.1 is found on N-CAM and other cell adhesion molecules. Brain Research 559: 118-129.

Naegele JR and Katz LC (1990) Cell surface molecules containing N-acetylgalactosamine are associated with basket and neurogliaform cells in cat visual cortex. J Neurosci 10:540-557.

Zaremba S, Naegele JR, Barnstable CJ, and Hockfield S (1990) Neuronal subsets express multiple high-molecular-weight cell-surface glycoconjugates defined by monoclonal antibodies Cat-301 and VC1.1. J Neurosci 10:2985-2995.

Naegele JR, Arimatsu Y, Schwartz P, and Barnstable CJ (1988) Selective staining of a subset of GABAergic neurons in cat visual cortex by monoclonal antibody VC1.1. J Neurosci 8:79-89.

Naegele JR, Jhaveri S, and Schneider GE (1988) Sharpening of topographical projections and maturation of geniculocortical axon arbors in the hamster. J Comp Neurol 277:593-607.

Arimatsu Y, Naegele JR, Barnstable CJ (1987) Molecular markers of neuronal subpopulations in layers 4, 5 and 6 of cat primary visual cortex. J Neurosci 7:1250-1263.

Birch EE, Gwiazda J, Bauer J, Naegele JR, and Held R (1983) Visual acuity and its meridional variations in children aged 7-60 months. Vision Research 23:1019-1024.

Naegele JR and Held R (1982) The postnatal development of monocular optokinetic nystagmus in infants. Vision Research 22:341-346.

Review articles and Commentaries:

Naegele JR (2019) Transplanted GABA progenitors synaptically inhibit new granule cells, reducing dendritic growth. (in press).

Zhu Q, Naegele JR, Chung S (2018) Cortical GABAergic interneuron/progenitor transplantation as a novel therapy for intractable epilepsy. Minireview. Frontiers in Cellular Neuroscience 2018 Jun 26;12:167. doi: 10.3389/fncel.2018.00167. eCollection 2018. Review. PMID: 29997478

Naegele JR (2018) Where does the controversial finding that adult human brains don’t grow new neurons leave ongoing research? The Conversation US, March 2018

Naegele JR (2016) Synaptic sweet talk: how do perineuronal nets contribute to epileptogenesis and neuroplasticity? Epilepsy Currents Jan/Feb 16(1):29-30.

Naegele JR (2015) Blocking astrocyte transformation at the dysfunctional blood-brain barrier. Epilepsy Currents. March/April 15(2): 1-3.

Naegele JR, Grabel LB, and Aaron, G (2015) Immature interneurons create a lasting impression. Epilepsy Currents. May/June 15(3): 1-3.

Gupta J, Naegele JR (2015) The art of setting limits: lessons from GABAergic interneuron transplantation. Epilepsy Currents. Nov/December 15(6): 347-348.

Naegele JR (2012) CLC-3: A quantum leap in understanding mechanisms of GABA release. Epilepsy Currents. Jan; 12(1): 17-8.

Naegele JR (2012) SAVAs: Molecular snipers for silencing GABAergic interneurons. Epilepsy Currents. 12(6) Nov/Dec. 12(6): 216-217.

Naegele JR (2011) Tangled roots: digging deeper into astrocyte or interneuron dysfunction in temporal lobe epilepsy. Epilepsy Currents 11(1): 27-9.

Naegele JR (2011) Should I stay or should I go? Epilepsy Currents 11(4): 123-4.

Naegele JR (2010) Westward Ho! Pioneering mouse models for X-linked infantile spasms syndrome. Epilepsy Currents 10(1): 24-7.

Naegele JR, Maisano X, Yang J, Royston S, Ribeiro E. (2010) Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy. Neuropharmacology 58(6): 855-864.

Naegele JR (2010) Trekking through the telencephalon: hepatocyte growth factor-mediated guidance for parvalbumin-expressing interneurons. Epilepsy Currents 10(4): 100-102.

Naegele JR, Vemuri MC, Studer L (2010) Embryonic stem cell therapy for intractable epilepsy. Epilepsia 51: 93.

Maisano X, Carpentino J, Becker S, Lanza R, Aaron G, Grabel G, Naegele JR (2009). Embryonic stem cell-derived neural precursor grafts for treatment of temporal lobe epilepsy Neurotherapeutics 6(2): 263-77.

Naegele JR (2009) Epilepsy and the plastic mind. Epilepsy Currents 9(6): 166-169.

Naegele JR (2007) Neuroprotective strategies to avert seizure-induced neurodegeneration in epilepsy. Epilepsia, 48 (Supplement 2): 1-11.
Chechlacz M and Naegele JR (2002) Genetics of childhood disorders: XL. Stem cell research, part 4: neural horticulture. J Am Acad Child Adolescent Psychiatry 41:882-885.

Naegele JR and Lombroso PJ (2001) Genetics of Central Nervous System developmental disorders. In (Todd, R. Ed.) Genetic Contributions to Early-Onset Psychopathology; Child and Adolescent Psychiatric Clinics of North America 10:225-239.

Naegele JR and Lombroso P (1994) Protein tyrosine phosphatases in the Nervous System. Critical Rev in Neurobiology 9:105-114.

Naegele JR and Barnstable CJ (1989) Molecular determinants of GABAergic local circuit neurons in the cerebral cortex. Trends in Neuroscience 12:28-34.

Book Chapters:

Van Zandt M, Naegele JR (2017) GABAergic Synapse Dysfunction and Repair in Temporal Lobe Epilepsy. In: Synaptic Plasticity, ISBN 978-953-51-5036-7, InTech.

Naegele JR, Vemuri MC, Studer L (2012). Embryonic stem cell therapy for intractable epilepsy. Jasper’s Basic Mechanisms of the Epilepsies. Noebels, J, Avoli M, Rogawski M, Olsen R, Delgado-Escueta AV (Eds). [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. PMID: 22787645

Hartman NW, Grabel LB, Naegele JR (2010) Migration of transplanted neural stem cells in experimental models of neurodegenerative diseases. Stem Cells and Regenerative Medicine. Appasani K (Ed.) Springer Science.

Naegele JR and Maisano X (2010) Gene and stem cell therapies for treating epilepsy. Epilepsy: Mechanisms, Models, and Translational Perspectives, CRC Press. Rho JM, Sankar R, Stafstrom CE (Eds.). Pp. 589-608.

Upender M and Naegele JR (1996) Preparation and growth of embryonic neurons in tissue culture. In: Neuroscience Methods (D.G. Blackburn, ed.). Trinity College Press, Hartford, CT.

Naegele JR and Held R (1983) Development of optokinetic nystagmus and the effects of abnormal visual experience during infancy. In: Jeannerod M, and Hein A (eds.) Spatially Guided Behavior. Springer-Verlag, pp. 155-174.